GSBS Student Publications

Title

Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos

Publication Date

2005-08-04

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

beta-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of beta-catenin contributes to numerous forms of cancer in humans. Here we describe Caenorhabditis elegans conditional alleles of mom-2/Wnt, mom-4/Tak1, and wrm-1/beta-catenin. We use these reagents to examine the regulation of WRM-1/beta-catenin during a Wnt-signaling-induced asymmetric cell division. While WRM-1 protein initially accumulates in the nuclei of all cells, signaling promotes the retention of WRM-1 in nuclei of responding cells. We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of beta-catenin during polarized cell division.

DOI of Published Version

10.1101/gad.1323705

Source

Genes Dev. 2005 Aug 1;19(15):1749-54. Link to article on publisher's site

Journal/Book/Conference Title

Genes and development

Related Resources

Link to article in PubMed

PubMed ID

16077004

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