GSBS Student Publications

Title

Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13

Publication Date

2007-01-16

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes gammadelta T cell development while opposing alphabeta T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of gammadelta T cells but not alphabeta T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.

DOI of Published Version

10.1126/science.1135344

Source

Science. 2007 Jan 12;315(5809):230-3. Link to article on publisher's site

Journal/Book/Conference Title

Science (New York, N.Y.)

Related Resources

Link to article in PubMed

PubMed ID

17218525

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