Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
Graduate School of Biomedical Sciences; Department of Pathology
Life Sciences | Medicine and Health Sciences
alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes gammadelta T cell development while opposing alphabeta T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of gammadelta T cells but not alphabeta T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.
DOI of Published Version
Science. 2007 Jan 12;315(5809):230-3. Link to article on publisher's site
Science (New York, N.Y.)
Melichar HJ, Narayan K, Der SD, Hiraoka Y, Gardiol N, Jeannet G, Held W, Chambers CA, Kang J. (2007). Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. GSBS Student Publications. https://doi.org/10.1126/science.1135344. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/849