Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology
Life Sciences | Medicine and Health Sciences
Experiments designed to distinguish virus-specific from non-virus-specific T cells showed that bystander T cells underwent apoptosis and substantial attrition in the wake of a strong T-cell response. Memory CD8 T cells (CD8(+) CD44(hi)) were most affected. During acute viral infection, transgenic T cells that were clearly defined as non-virus specific decreased in number and showed an increase in apoptosis. Also, use of lymphocytic choriomeningitis virus (LCMV) carrier mice, which lack LCMV-specific T cells, showed a significant decline in non-virus-specific memory CD8 T cells that correlated to an increase in apoptosis in response to the proliferation of adoptively transferred virus-specific T cells. Attrition of T cells early during infection correlated with the alpha/beta interferon (IFN-alpha/beta) peak, and the IFN inducer poly(I:C) caused apoptosis and attrition of CD8(+) CD44(hi) T cells in normal mice but not in IFN-alpha/beta receptor-deficient mice. Apoptotic attrition of bystander T cells may make room for the antigen-specific expansion of T cells during infection and may, in part, account for the loss of T-cell memory that occurs when the host undergoes subsequent infections.
DOI of Published Version
J Virol. 2001 Jul;75(13):5965-76. Link to article on publisher's site
Journal of virology
McNally, James M.; Zarozinski, Christopher C.; Lin, Meei Y.; Brehm, Michael A.; Chen, Hong D.; and Welsh, Raymond M., "Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses" (2001). GSBS Student Publications. 839.