Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology
Medical Subject Headings
Adoptive Transfer; Animals; Antigens, CD44; CD8-Positive T-Lymphocytes; Immunologic Memory; Interferon Type II; Interferon-alpha; Interferon-beta; Killer Cells, Natural; Lymphocytic Choriomeningitis; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Perforin; Poly I-C; Pore Forming Cytotoxic Proteins; T-Lymphocytes
Life Sciences | Medicine and Health Sciences
Experiments designed to distinguish virus-specific from non-virus-specific T cells showed that bystander T cells underwent apoptosis and substantial attrition in the wake of a strong T-cell response. Memory CD8 T cells (CD8(+) CD44(hi)) were most affected. During acute viral infection, transgenic T cells that were clearly defined as non-virus specific decreased in number and showed an increase in apoptosis. Also, use of lymphocytic choriomeningitis virus (LCMV) carrier mice, which lack LCMV-specific T cells, showed a significant decline in non-virus-specific memory CD8 T cells that correlated to an increase in apoptosis in response to the proliferation of adoptively transferred virus-specific T cells. Attrition of T cells early during infection correlated with the alpha/beta interferon (IFN-alpha/beta) peak, and the IFN inducer poly(I:C) caused apoptosis and attrition of CD8(+) CD44(hi) T cells in normal mice but not in IFN-alpha/beta receptor-deficient mice. Apoptotic attrition of bystander T cells may make room for the antigen-specific expansion of T cells during infection and may, in part, account for the loss of T-cell memory that occurs when the host undergoes subsequent infections.
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Citation: J Virol. 2001 Jul;75(13):5965-76. Link to article on publisher's site
DOI of Published Version
Journal of virology
McNally, James M.; Zarozinski, Christopher C.; Lin, Meei Y.; Brehm, Michael A.; Chen, Hong D.; and Welsh, Raymond M., "Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses" (2001). GSBS Student Publications. 839.