Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2
Department of Neurobiology; Budnik Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Neuroscience and Neurobiology
Wingless secretion provides pivotal signals during development by activating transcription of target genes. At Drosophila synapses, Wingless is secreted from presynaptic terminals and is required for synaptic growth and differentiation. Wingless binds the seven-pass transmembrane DFrizzled2 receptor, but the ensuing events at synapses are not known. We show that DFrizzled2 is endocytosed from the postsynaptic membrane and transported to the nucleus. The C terminus of DFrizzled2 is cleaved and translocated into the nucleus; the N-terminal region remains just outside the nucleus. Translocation of DFrizzled2-C into the nucleus, but not its cleavage and transport, depends on Wingless signaling. We conclude that, at synapses, Wingless signal transduction occurs through the nuclear localization of DFrizzled2-C for potential transcriptional regulation of synapse development.
DOI of Published Version
Science. 2005 Nov 25;310(5752):1344-7. Link to article on publisher's site
Science (New York, N.Y.)
Mathew, Dennis; Ataman, Bulent; Chen, Jinyun; Zhang, Yali; Cumberledge, Susan; and Budnik, Vivian, "Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2" (2005). GSBS Student Publications. 820.