GSBS Student Publications

Title

The Chd family of chromatin remodelers

Publication Date

2007-03-14

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease.

DOI of Published Version

10.1016/j.mrfmmm.2006.07.012

Source

Mutat Res. 2007 May 1;618(1-2):30-40. Epub 2007 Jan 21. Link to article on publisher's site

Journal/Book/Conference Title

Mutation research

Related Resources

Link to article in PubMed

PubMed ID

17350655

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