The Chd family of chromatin remodelers
Graduate School of Biomedical Sciences; Department of Cell Biology
Life Sciences | Medicine and Health Sciences
Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease.
DOI of Published Version
Mutat Res. 2007 May 1;618(1-2):30-40. Epub 2007 Jan 21. Link to article on publisher's site
Marfella CG, Imbalzano AN. (2007). The Chd family of chromatin remodelers. GSBS Student Publications. https://doi.org/10.1016/j.mrfmmm.2006.07.012. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/805