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Document Type
Journal ArticlePublication Date
2007-03-14Keywords
Adenosine Triphosphate; Animals; Chromatin; Chromatin Assembly and Disassembly; DNA; DNA-Binding Proteins; Drosophila melanogaster; Humans; Models, Genetic; Multigene Family; *Mutation; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae Proteins; Transcription, GeneticLife Sciences
Medicine and Health Sciences
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Show full item recordAbstract
Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease.Source
Mutat Res. 2007 May 1;618(1-2):30-40. Epub 2007 Jan 21. Link to article on publisher's siteDOI
10.1016/j.mrfmmm.2006.07.012Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34145PubMed ID
17350655Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.mrfmmm.2006.07.012