Biophysical mechanism of the scavenger site near T cell-presented epitopes
Graduate School of Biomedical Sciences; Department of Pharmacology
Life Sciences | Medicine and Health Sciences
We seek to identify consensus sequences in digested fragments of antigenic proteins regulating selection and major histocompatibility complex (MHC)-restricted presentation to T cells of epitopes within those fragments. One such pattern, of recurrent, hydrophobic sidechains forming a longitudinal hydrophobic strip when a sequence is coiled as an alpha-helix, is found in or near most T cell-presented epitopes. Such recurrent hydrophobicity may lead to protease-protected coiling of the fragment against endosomal membranes and transfer to MHC molecules. This concept leads to better identification of T cell-presented sequences and possible to engineering of T cell-presented vaccines to affect their potency and MHC restriction.
Lu S, Reyes VE, Bositis CM, Goldschmidt TG, Lam V, Torgerson RR, Ciardelli T, Hardy LW, Lew RA, Humphreys RE. (1992). Biophysical mechanism of the scavenger site near T cell-presented epitopes. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/786