GSBS Student Publications

Title

Evolution of the CD8 T-cell repertoire during infections

Publication Date

2000-09-01

UMMS Affiliation

Graduate School of Biomedical Sciences; The Department of Pathology and Program in Immunology and Virology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.

Source

Microbes Infect. 2000 Jul;2(9):1025-39.

Journal/Book/Conference Title

Microbes and infection / Institut Pasteur

Related Resources

Link to article in PubMed

PubMed ID

10967283

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