Evolution of the CD8 T-cell repertoire during infections
Graduate School of Biomedical Sciences; The Department of Pathology and Program in Immunology and Virology
Medical Subject Headings
Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Flow Cytometry; Herpesvirus 4, Human; Interferon Type II; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Antigen, T-Cell, alpha-beta; Spleen; T-Lymphocyte Subsets; Virus Latency
Life Sciences | Medicine and Health Sciences
CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.
Rights and Permissions
Citation: Microbes Infect. 2000 Jul;2(9):1025-39.
Microbes and infection / Institut Pasteur
Lin, Meei-Yun; Selin, Liisa K.; and Welsh, Raymond M., "Evolution of the CD8 T-cell repertoire during infections" (2000). GSBS Student Publications. 764.