Title
Evolution of the CD8 T-cell repertoire during infections
UMMS Affiliation
Graduate School of Biomedical Sciences; The Department of Pathology and Program in Immunology and Virology
Publication Date
2000-09-01
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.
Source
Microbes Infect. 2000 Jul;2(9):1025-39.
Journal/Book/Conference Title
Microbes and infection / Institut Pasteur
Related Resources
PubMed ID
10967283
Repository Citation
Lin M, Selin LK, Welsh RM. (2000). Evolution of the CD8 T-cell repertoire during infections. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/764