Title
Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation
Academic Program
Cell Biology
UMMS Affiliation
Department of Cell Biology
Publication Date
1998-12-20
Document Type
Article
Disciplines
Cell Biology | Life Sciences | Medicine and Health Sciences
Abstract
The bone tissue-specific osteocalcin gene remains one of a few genes that exhibits osteoblast-restricted expression. Over the last decade, characterization of the promoter regulatory elements and complexes of factors that control suppression of the osteocalcin gene in osteoprogenitor cells and transactivation in mature osteoblasts has revealed transcriptional regulatory mechanisms that mediate development of the osteoblast phenotype. In this review, we have focused on emerging concepts related to molecular mechanisms supporting osteoblast growth and differentiation based on the discoveries that the osteocalcin gene is regulated by homeodomain factors, AP-1 related proteins, and the bone restricted Cbfa1/AML3 transcription factor.
Source
J Cell Biochem Suppl. 1998;30-31:62-72.
Journal/Book/Conference Title
Journal of cellular biochemistry. Supplement
Related Resources
PubMed ID
9893257
Repository Citation
Lian JB, Stein GS, Stein JL, Van Wijnen AJ. (1998). Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation. GSBS Student Publications. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/690