GSBS Student Publications
Title
Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation
GSBS Program
Cell Biology
UMMS Affiliation
Department of Cell Biology
Date
12-20-1998
Document Type
Article
Medical Subject Headings
Animals; Cell Differentiation; Cell Division; Gene Expression Regulation, Developmental; Humans; Osteoblasts; Osteocalcin; Promoter Regions (Genetics)
Disciplines
Cell Biology | Life Sciences | Medicine and Health Sciences
Abstract
The bone tissue-specific osteocalcin gene remains one of a few genes that exhibits osteoblast-restricted expression. Over the last decade, characterization of the promoter regulatory elements and complexes of factors that control suppression of the osteocalcin gene in osteoprogenitor cells and transactivation in mature osteoblasts has revealed transcriptional regulatory mechanisms that mediate development of the osteoblast phenotype. In this review, we have focused on emerging concepts related to molecular mechanisms supporting osteoblast growth and differentiation based on the discoveries that the osteocalcin gene is regulated by homeodomain factors, AP-1 related proteins, and the bone restricted Cbfa1/AML3 transcription factor.
Rights and Permissions
Citation: J Cell Biochem Suppl. 1998;30-31:62-72.
Related Resources
Journal Title
Journal of cellular biochemistry. Supplement
PubMed ID
9893257
Repository Citation
Lian, Jane B.; Stein, Gary S.; Stein, Janet L.; and Van Wijnen, Andre J., "Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation" (1998). GSBS Student Publications. 690.
https://escholarship.umassmed.edu/gsbs_sp/690