GSBS Student Publications

Title

Genomic loci of human mitogen-activated protein kinases

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

1994-02-01

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine and Howard Hughes Medical Institute

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Mitogen-activated protein (MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. Several components of the MAP kinase signal transduction pathway have been demonstrated to be oncogenically activated in malignant tumors. These include growth factor receptors, the GTP-binding protein Ras, and the protein kinase Raf. The genes that encode MAP kinases therefore represent potential targets of carcinogenic insults. Here, we report the genomic loci of three MAP kinase genes are widely distributed within the human genome: p41mapk (Erk2) at 22q11.2; p44mapk (Erk1) at 16p11.2; and p63mapk (Erk3-related) at 18q12-21.

Source

Oncogene. 1994 Feb;9(2):647-9.

Journal/Book/Conference Title

Oncogene

Related Resources

Link to article in PubMed

PubMed ID

8290275

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