A profound deficiency in thymic progenitor cells in mice lacking Jak3
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Department of Pathology
Life Sciences | Medicine and Health Sciences
Humans and mice with genetic deficiencies that lead to loss of signaling through common gamma-chain (gammac)-containing cytokine receptors have severe defects in B and T lymphocytes. In humans, these deficiencies lead to a complete absence of T cells, whereas in mice, small thymuses give rise to normal numbers of peripheral T cells. We have examined the first wave of developing T cells in Jak3-/-, IL-7-/-, and IL-7Ralpha-/- fetal mice, and have found a near absence of thymic progenitor cells. This deficiency is highlighted by the complete inability of Jak3-/- progenitor cells to reconstitute T cell development in the presence of competing wild-type cells. These data clearly demonstrate a strong common basis for the T cell deficiencies in mice and humans lacking gammac/Jak3 signaling pathways.
J Immunol. 2000 Oct 1;165(7):3680-8.
Journal of immunology (Baltimore, Md. : 1950)
Baird, Allison Michelle; Lucas, Julie Ann; and Berg, Leslie J., "A profound deficiency in thymic progenitor cells in mice lacking Jak3" (2000). GSBS Student Publications. 68.