Title
A profound deficiency in thymic progenitor cells in mice lacking Jak3
UMMS Affiliation
Graduate School of Biomedical Sciences; Department of Pathology
Publication Date
2000-10-18
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Humans and mice with genetic deficiencies that lead to loss of signaling through common gamma-chain (gammac)-containing cytokine receptors have severe defects in B and T lymphocytes. In humans, these deficiencies lead to a complete absence of T cells, whereas in mice, small thymuses give rise to normal numbers of peripheral T cells. We have examined the first wave of developing T cells in Jak3-/-, IL-7-/-, and IL-7Ralpha-/- fetal mice, and have found a near absence of thymic progenitor cells. This deficiency is highlighted by the complete inability of Jak3-/- progenitor cells to reconstitute T cell development in the presence of competing wild-type cells. These data clearly demonstrate a strong common basis for the T cell deficiencies in mice and humans lacking gammac/Jak3 signaling pathways.
DOI of Published Version
10.4049/jimmunol.165.7.3680
Source
J Immunol. 2000 Oct 1;165(7):3680-8.
Journal/Book/Conference Title
Journal of immunology (Baltimore, Md. : 1950)
Related Resources
PubMed ID
11034372
Repository Citation
Baird AM, Lucas JA, Berg LJ. (2000). A profound deficiency in thymic progenitor cells in mice lacking Jak3. GSBS Student Publications. https://doi.org/10.4049/jimmunol.165.7.3680. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/68