GSBS Student Publications


Amorphous no longer: the centrosome comes into focus

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine



Document Type


Medical Subject Headings

Animals; Cell Nucleus; Centrosome; Microtubules; Mitosis; Models, Biological; Neoplasms; Tubulin


Life Sciences | Medicine and Health Sciences


Recent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly of proteins onto centrosomes and regulation of centrosome duplication and separation are being defined. Characterization of centrosome function, together with studies implicating centrosomes in tumorigenesis and demonstrating that centrosomes are highly organized, are beginning to bring into focus an organelle once viewed as an 'amorphous cloud'.

Rights and Permissions

Citation: Curr Opin Cell Biol. 1999 Feb;11(1):122-8.

Related Resources

Link to Article in PubMed

Journal Title

Current opinion in cell biology

PubMed ID