GSBS Student Publications

Title

Amorphous no longer: the centrosome comes into focus

Publication Date

1999-02-27

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Recent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly of proteins onto centrosomes and regulation of centrosome duplication and separation are being defined. Characterization of centrosome function, together with studies implicating centrosomes in tumorigenesis and demonstrating that centrosomes are highly organized, are beginning to bring into focus an organelle once viewed as an 'amorphous cloud'.

Source

Curr Opin Cell Biol. 1999 Feb;11(1):122-8.

Journal/Book/Conference Title

Current opinion in cell biology

Related Resources

Link to Article in PubMed

PubMed ID

10047524

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