GSBS Student Publications

Title

Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles

Publication Date

2001-02-24

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Centrosomes and other microtubule organizing centers are the largest non-membranous organelles in most cells. This morphologically diverse class of organelles shares a common ability to nucleate and organize microtubules in interphase and participates in the formation of mitotic spindles during cell division. This review summarizes recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein.

Source

Traffic. 2000 Dec;1(12):927-34.

Journal/Book/Conference Title

Traffic (Copenhagen, Denmark)

Related Resources

Link to Article in PubMed

PubMed ID

11208082

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