Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences
Centrosomes and other microtubule organizing centers are the largest non-membranous organelles in most cells. This morphologically diverse class of organelles shares a common ability to nucleate and organize microtubules in interphase and participates in the formation of mitotic spindles during cell division. This review summarizes recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein.
DOI of Published Version
Traffic. 2000 Dec;1(12):927-34.
Traffic (Copenhagen, Denmark)
Zimmerman WC, Doxsey SJ. (2001). Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1111/j.1600-0854.2000.11202.x. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/663