Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4

Mary Ellen Lane
Alexander Peter Runko, University of Massachusetts Medical School
Nicole Marie Roy, University of Massachusetts Medical School
Charles G. Sagerstrom, University of Massachusetts Medical School

Document Type Article

Abstract

We report the expression of zebrafish lmo4 during the first 48 h of development. Like its murine ortholog, lmo4 is expressed in somitic mesoderm, branchial arches, otic vesicles, and limb (pectoral fin) buds. In addition, however, we report zebrafish lmo4 expression in the developing eye, cardiovascular tissue, and the neural plate and telencephalon. We demonstrate that expression in the rostral hindbrain requires acerebellar (ace/fgf8) and spiel ohne grenzen (spg/pou2) activity.