GSBS Student Publications

Title

Drosophila olfactory memory: single genes to complex neural circuits

Student Author(s)

Alex Keene

GSBS Program

Neuroscience

Publication Date

2007-5

UMMS Affiliation

Department of Neurobiology; Waddell Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Document Type

Article

Disciplines

Neuroscience and Neurobiology

Abstract

A central goal of neuroscience is to understand how neural circuits encode memory and guide behaviour. Studying simple, genetically tractable organisms, such as Drosophila melanogaster, can illuminate principles of neural circuit organization and function. Early genetic dissection of D. melanogaster olfactory memory focused on individual genes and molecules. These molecular tags subsequently revealed key neural circuits for memory. Recent advances in genetic technology have allowed us to manipulate and observe activity in these circuits, and even individual neurons, in live animals. The studies have transformed D. melanogaster from a useful organism for gene discovery to an ideal model to understand neural circuit function in memory.

DOI of Published Version

10.1038/nrn2098

Source

Nat Rev Neurosci. 2007 May;8(5):341-54. Link to article on publisher's site

Journal/Book/Conference Title

Nature reviews. Neuroscience

Related Resources

Link to article in PubMed

PubMed ID

17453015

Share

COinS