Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output
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Authors
Keene, Alex CarlStratmann, Markus
Keller, Andreas
Perrat, Paola N.
Vosshall, Leslie B.
Waddell, Scott
Student Authors
Alex KeenePaola Perrat
Academic Program
NeuroscienceUMass Chan Affiliations
Graduate School of Biomedical Sciences, Neuroscience ProgramWaddell Lab
Neurobiology
Document Type
Journal ArticlePublication Date
2004-10-28Keywords
Analysis of Variance; Animals; Animals, Genetically Modified; Avoidance Learning; Behavior, Animal; Benzaldehydes; Brain; Conditioning (Psychology); Drosophila; Drosophila Proteins; Fushi Tarazu Transcription Factors; Histocytochemistry; Maze Learning; Memory; Microscopy, Confocal; Mushroom Bodies; Mutagenesis; Neurons; Neuropeptides; *Odors; Olfactory Pathways; Recombinant Fusion Proteins; Temperature; Time Factors; Trans-ActivatorsNeuroscience and Neurobiology
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Show full item recordAbstract
Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration.Source
Neuron. 2004 Oct 28;44(3):521-33. Link to article on publisher's siteDOI
10.1016/j.neuron.2004.10.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33943PubMed ID
15504331Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.neuron.2004.10.006