Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output
Department of Neurobiology; Waddell Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Neuroscience and Neurobiology
Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration.
DOI of Published Version
Neuron. 2004 Oct 28;44(3):521-33. Link to article on publisher's site
Keene AC, Stratmann M, Keller A, Perrat PN, Vosshall LB, Waddell S. (2004). Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1016/j.neuron.2004.10.006. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/596