GSBS Student Publications
Title
Cutting edge: MHC class II-restricted killing in vivo during viral infection
GSBS Program
Biochemistry & Molecular Pharmacology
Publication Date
2005-01-07
UMMS Affiliation
Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
DOI of Published Version
10.4049/jimmunol.174.2.614
Source
J Immunol. 2005 Jan 15;174(2):614-8.
Journal/Book/Conference Title
Journal of immunology (Baltimore, Md. : 1950)
Related Resources
PubMed ID
15634878
Repository Citation
Jellison, Evan Robert; Kim, Sung-Kwon; and Welsh, Raymond M., "Cutting edge: MHC class II-restricted killing in vivo during viral infection" (2005). GSBS Student Publications. 585.
https://escholarship.umassmed.edu/gsbs_sp/585