Cutting edge: MHC class II-restricted killing in vivo during viral infection
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology
Life Sciences | Medicine and Health Sciences
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
DOI of Published Version
J Immunol. 2005 Jan 15;174(2):614-8.
Journal of immunology (Baltimore, Md. : 1950)
Jellison, Evan Robert; Kim, Sung-Kwon; and Welsh, Raymond M., "Cutting edge: MHC class II-restricted killing in vivo during viral infection" (2005). GSBS Student Publications. 585.