GSBS Student Publications

Title

Cutting edge: MHC class II-restricted killing in vivo during viral infection

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2005-01-07

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.

Source

J Immunol. 2005 Jan 15;174(2):614-8.

Journal/Book/Conference Title

Journal of immunology (Baltimore, Md. : 1950)

Related Resources

Link to article in PubMed

PubMed ID

15634878

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