Cutting edge: MHC class II-restricted killing in vivo during viral infection
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Immunology and Virology; Department of Pathology
Life Sciences | Medicine and Health Sciences
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
DOI of Published Version
J Immunol. 2005 Jan 15;174(2):614-8.
Journal of immunology (Baltimore, Md. : 1950)
Jellison ER, Kim S, Welsh RM. (2005). Cutting edge: MHC class II-restricted killing in vivo during viral infection. GSBS Student Publications. https://doi.org/10.4049/jimmunol.174.2.614. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/585