GSBS Student Publications

Title

Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

1995-11-01

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Neuroscience

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Clinical trials are under way using fetal cells to repair damaged neuronal circuitry. However, little is known about how transplanted immature neurons can grow anatomically correct connections in the adult central nervous system (CNS). We transplanted embryonic porcine neural cells in vivo into adult rat brains with neuronal and axonal loss typical of Parkinson's or Huntington's disease. Using complementary species-specific cellular markers, we found donor axons and CD44+ astroglial fibres in host white matter tracts up to 8 mm from CNS transplant sites, although only donor axons were capable of reaching correct gray matter target regions. This work demonstrates that adult host brain can orient growth of transplanted neurons and that there are differences in transplant donor glial and axonal growth patterns in cellular repair of the mature CNS.

Source

Nat Med. 1995 Nov;1(11):1189-94.

Journal/Book/Conference Title

Nature medicine

Related Resources

Link to article in PubMed

PubMed ID

7584993

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