Authors
Houghton, JeanMarieStoicov, Calin
Nomura, Sachiyo
Rogers, Arlin B.
Carlson, Jane E.
Li, Hanchen
Cai, Xun
Fox, James G.
Goldenring, James R.
Wang, Timothy C.
Student Authors
Calin Stoicov,UMass Chan Affiliations
Department of Cancer BiologyDepartment of Medicine, Division of Gastroenterology
Document Type
Journal ArticlePublication Date
2004-11-30Keywords
Animals; Apoptosis; Bone Marrow Cells; Bone Marrow Transplantation; Carcinoma in Situ; Cell Differentiation; Cell Fusion; Disease Progression; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; *Helicobacter felis; Keratins; Male; Mesenchymal Stem Cells; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mucins; Muscle Proteins; Parietal Cells, Gastric; Peptides; Phenotype; Stem Cells; Stomach NeoplasmsGastroenterology
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.Source
Science. 2004 Nov 26;306(5701):1568-71. Link to article on publisher's siteDOI
10.1126/science.1099513Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33892PubMed ID
15567866Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1126/science.1099513