Gastric cancer originating from bone marrow-derived cells
Department of Medicine, Division of Gastroenterology; Department of Cancer Biology
Gastroenterology | Life Sciences | Medicine and Health Sciences
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.
DOI of Published Version
Science. 2004 Nov 26;306(5701):1568-71. Link to article on publisher's site
Science (New York, N.Y.)
Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson JE, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. (2004). Gastric cancer originating from bone marrow-derived cells. GSBS Student Publications. https://doi.org/10.1126/science.1099513. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/548