Gastric cancer originating from bone marrow-derived cells
Department of Medicine, Division of Gastroenterology; Department of Cancer Biology
Gastroenterology | Life Sciences | Medicine and Health Sciences
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.
DOI of Published Version
Science. 2004 Nov 26;306(5701):1568-71. Link to article on publisher's site
Science (New York, N.Y.)
Houghton, JeanMarie; Stoicov, Calin; Nomura, Sachiyo; Rogers, Arlin B.; Carlson, Jane E.; Li, Hanchen; Cai, Xun; Fox, James G.; Goldenring, James R.; and Wang, Timothy C., "Gastric cancer originating from bone marrow-derived cells" (2004). GSBS Student Publications. 548.