SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences
Post-translational modification of nucleosomal histones has been suggested to contribute to epigenetic transcriptional memory. We describe a case of transcriptional memory in yeast where the rate of transcriptional induction of GAL1 is regulated by the prior expression state. This epigenetic state is inherited by daughter cells, but does not require the histone acetyltransferase, Gcn5p, the histone ubiquitinylating enzyme, Rad6p, or the histone methylases, Dot1p, Set1p, or Set2p. In contrast, we show that the ATP-dependent chromatin remodeling enzyme, SWI/SNF, is essential for transcriptional memory at GAL1. Genetic studies indicate that SWI/SNF controls transcriptional memory by antagonizing ISWI-like chromatin remodeling enzymes.
DOI of Published Version
Genes Dev. 2007 Apr 15;21(8):997-1004. Link to article on publisher's site
Genes and development
Kundu, Sharmistha; Horn, Peter J.; and Peterson, Craig L., "SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster" (2007). GSBS Student Publications. 505.