GSBS Student Publications

Title

RNAi (Nematodes: Caenorhabditis elegans)

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2002-04-05

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

RNA interference in Caenorhabditis elegans is a type of homology dependent posttranscriptional gene silencing induced by dsRNA. In this chapter we describe the history of the discovery of RNAi, its systemic nature, inheritance, and connection to other homology-dependent silencing phenomena like co-suppression and transcriptional gene silencing. We discuss RNAi-deficient mutants in C. elegans as well as characterized components of the RNAi, pathway, the molecular mechanism of RNAi, and its possible role in development and immunity.

DOI of Published Version

10.1016/S0065-2660(02)46013-0

Source

Adv Genet. 2002;46:339-60.

Journal/Book/Conference Title

Advances in genetics

Related Resources

Link to article in PubMed

PubMed ID

11931230

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