GSBS Student Publications

Title

In and out of the ER: protein folding, quality control, degradation, and related human diseases

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2007-10-12

UMMS Affiliation

Graduate School of Biomedical Sciences

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter cotranslationally in the ER lumen, which contains resident molecular chaperones and folding factors that assist their maturation. Native proteins are released from the ER lumen and are transported through the secretory pathway to their final intra- or extracellular destination. Folding-defective polypeptides are exported across the ER membrane into the cytosol and destroyed. Cellular and organismal homeostasis relies on a balanced activity of the ER folding, quality control, and degradation machineries as shown by the dozens of human diseases related to defective maturation or disposal of individual polypeptides generated in the ER.

DOI of Published Version

10.1152/physrev.00050.2006

Source

Physiol Rev. 2007 Oct;87(4):1377-408. Link to article on publisher's site

Journal/Book/Conference Title

Physiological reviews

Related Resources

Link to Article in PubMed

PubMed ID

17928587

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