GSBS Student Publications
Title
Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption
GSBS Program
Biochemistry & Molecular Pharmacology
Publication Date
2007-12-20
UMMS Affiliation
Graduate School of Biomedical Sciences
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Enhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.
DOI of Published Version
10.1038/sj.jcbfm.9600598
Source
J Cereb Blood Flow Metab. 2008 May;28(5):882-6. Epub 2007 Dec 19. Link to article on publisher's site
Journal/Book/Conference Title
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Related Resources
PubMed ID
18091756
Repository Citation
Henning, Erica C.; Latour, Lawrence L.; and Warach, Steven, "Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption" (2007). GSBS Student Publications. 351.
https://escholarship.umassmed.edu/gsbs_sp/351