GSBS Student Publications


Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences



Document Type


Medical Subject Headings

Acute Disease; Aged; Blood-Brain Barrier; Cerebrospinal Fluid; Contrast Media; Extracellular Space; Gadolinium DTPA; Humans; Magnetic Resonance Imaging; Models, Neurological; Retrospective Studies; Stroke


Life Sciences | Medicine and Health Sciences


Enhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.

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Citation: J Cereb Blood Flow Metab. 2008 May;28(5):882-6. Epub 2007 Dec 19. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to Article in PubMed

Journal Title

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

PubMed ID