Title
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
UMMS Affiliation
Graduate School of Biomedical Sciences; Howard Hughes Medical Institute, Program in Molecular Medicine
Publication Date
2000-03-16
Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The p38 mitogen-activated protein kinase (MAPK) group is represented by four isoforms in mammals (p38alpha, p38beta2, p38gamma and p38delta). These p38 MAPK isoforms appear to mediate distinct functions in vivo due, in part, to differences in substrate phosphorylation by individual p38 MAPKs and also to selective activation by MAPK kinases (MAPKKs). Here we report the identification of two factors that contribute to the specificity of p38 MAPK activation. One mechanism of specificity is the selective formation of functional complexes between MAPKK and different p38 MAPKs. The formation of these complexes requires the presence of a MAPK docking site in the N-terminus of the MAPKK. The second mechanism that confers signaling specificity is the selective recognition of the activation loop (T-loop) of p38 MAPK isoforms. Together, these processes provide a mechanism that enables the selective activation of p38 MAPK in response to activated MAPKK.
DOI of Published Version
10.1093/emboj/19.6.1301
Source
EMBO J. 2000 Mar 15;19(6):1301-11. Link to article on publisher's site
Journal/Book/Conference Title
The EMBO journal
Related Resources
PubMed ID
10716930
Repository Citation
Enslen H, Brancho DM, Davis RJ. (2000). Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. GSBS Student Publications. https://doi.org/10.1093/emboj/19.6.1301. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/343