Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans
UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2004-04-03Keywords
*Gene Expression Regulation; Genetic Complementation Test; Heat; Hela Cells; Humans; Hydrogen Peroxide; Mitochondria; Oxidants; Oxidation-Reduction; Oxidative Stress; Proteins; Reactive Oxygen Species; Saccharomyces cerevisiae; Tissue DistributionLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Reactive oxygen species (ROS) are critical molecules produced as a consequence of aerobic respiration. It is essential for cells to control the production and activity of such molecules in order to protect the genome and regulate cellular processes such as stress response and apoptosis. Mitochondria are the major source of ROS within the cell, and as a result, numerous proteins have evolved to prevent or repair oxidative damage in this organelle. The recently discovered OXR1 gene family represents a set of conserved eukaryotic genes. Previous studies of the yeast OXR1 gene indicate that it functions to protect cells from oxidative damage. In this report, we show that human and yeast OXR1 genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage. We also demonstrate that mitochondrial localization is required for Oxr1 protein to prevent oxidative damage.Source
Mol Cell Biol. 2004 Apr;24(8):3180-7.
DOI
10.1128/MCB.24.8.3180-3187.2004Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33674PubMed ID
15060142Related Resources
ae974a485f413a2113503eed53cd6c53
10.1128/MCB.24.8.3180-3187.2004