GSBS Student Publications

Title

microPrimer: the biogenesis and function of microRNA

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2005-10-15

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Biochemistry and Molecular Pharmacology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene expression profiles during plant and animal development. In fact, miRNAs may regulate as many as one-third of human genes. miRNAs are found only in plants and animals, and in the viruses that infect them. miRNAs function very much like siRNAs, but these two types of small RNAs can be distinguished by their distinct pathways for maturation and by the logic by which they regulate gene expression.

DOI of Published Version

10.1242/dev.02070

Source

Development. 2005 Nov;132(21):4645-52. Link to article on publisher's site

Journal/Book/Conference Title

Development (Cambridge, England)

Related Resources

Link to article in PubMed

PubMed ID

16224044

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