Membrane recognition and targeting by lipid-binding domains
Graduate School of Biomedical Sciences; Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology
Life Sciences | Medicine and Health Sciences
Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.
DOI of Published Version
Sci STKE. 2003 Dec 16;2003(213):re16. Link to article on publisher's site
Science's STKE : signal transduction knowledge environment
DiNitto JP, Cronin TC, Lambright DG. (2003). Membrane recognition and targeting by lipid-binding domains. GSBS Student Publications. https://doi.org/10.1126/stke.2132003re16. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/314