GSBS Student Publications

Title

Membrane recognition and targeting by lipid-binding domains

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2003-12-18

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.

DOI of Published Version

10.1126/stke.2132003re16

Source

Sci STKE. 2003 Dec 16;2003(213):re16. Link to article on publisher's site

Journal/Book/Conference Title

Science's STKE : signal transduction knowledge environment

Related Resources

Link to article in PubMed

PubMed ID

14679290

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