Endotoxin recognition and signal transduction by the TLR4/MD2-complex
Department of Medicine, Division of Infectious Diseases and Immunology
Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.
DOI of Published Version
Microbes Infect. 2004 Dec;6(15):1361-7. Link to article on publisher's site
Microbes and infection / Institut Pasteur
Fitzgerald KA, Rowe DC, Golenbock DT. (2004). Endotoxin recognition and signal transduction by the TLR4/MD2-complex. GSBS Student Publications. https://doi.org/10.1016/j.micinf.2004.08.015. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/293