GSBS Student Publications

Title

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

Student Author(s)

Daniel C. Rowe

Publication Date

2003-04-15

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Document Type

Article

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activation of IRF3 and NF-kappaB. Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IkappaB kinase homologs, IkappaB kinase-epsilon (IKKepsilon) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-kappaB activation, are also essential components of the IRF3 signaling pathway. Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response.

DOI of Published Version

10.1038/ni921

Source

Nat Immunol. 2003 May;4(5):491-6. Link to article on publisher's site

Journal/Book/Conference Title

Nature immunology

Related Resources

Link to article in PubMed

PubMed ID

12692549

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