Tec kinases in T cell and mast cell signaling

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Pathology

Publication Date


Document Type



Life Sciences | Medicine and Health Sciences


The Tec family of tyrosine kinases consists of five members (Itk, Rlk, Tec, Btk, and Bmx) that are expressed predominantly in hematopoietic cells. The exceptions, Tec and Bmx, are also found in endothelial cells. Tec kinases constitute the second largest family of cytoplasmic protein tyrosine kinases. While B cells express Btk and Tec, and T cells express Itk, Rlk, and Tec, all four of these kinases (Btk, Itk, Rlk, and Tec) can be detected in mast cells. This chapter will focus on the biochemical and cell biological data that have been accumulated regarding Itk, Rlk, Btk, and Tec. In particular, distinctions between the different Tec kinase family members will be highlighted, with a goal of providing insight into the unique functions of each kinase. The known functions of Tec kinases in T cell and mast cell signaling will then be described, with a particular focus on T cell receptor and mast cell Fc epsilon RI signaling pathways.

DOI of Published Version



Adv Immunol. 2007;93:145-84. Link to article on publisher's site

Journal/Book/Conference Title

Advances in immunology

Related Resources

Link to article in PubMed

PubMed ID