Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Document Type
Journal ArticlePublication Date
2007-03-27Keywords
Animals; Enzyme Activation; Humans; Mast Cells; Protein-Tyrosine Kinases; Signal Transduction; T-LymphocytesLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
The Tec family of tyrosine kinases consists of five members (Itk, Rlk, Tec, Btk, and Bmx) that are expressed predominantly in hematopoietic cells. The exceptions, Tec and Bmx, are also found in endothelial cells. Tec kinases constitute the second largest family of cytoplasmic protein tyrosine kinases. While B cells express Btk and Tec, and T cells express Itk, Rlk, and Tec, all four of these kinases (Btk, Itk, Rlk, and Tec) can be detected in mast cells. This chapter will focus on the biochemical and cell biological data that have been accumulated regarding Itk, Rlk, Btk, and Tec. In particular, distinctions between the different Tec kinase family members will be highlighted, with a goal of providing insight into the unique functions of each kinase. The known functions of Tec kinases in T cell and mast cell signaling will then be described, with a particular focus on T cell receptor and mast cell Fc epsilon RI signaling pathways.Source
Adv Immunol. 2007;93:145-84. Link to article on publisher's siteDOI
10.1016/S0065-2776(06)93004-1Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33613PubMed ID
17383541Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/S0065-2776(06)93004-1