A peptidyl transferase ribozyme capable of combinatorial peptide synthesis
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Medical Subject Headings
*Combinatorial Chemistry Techniques; Dipeptides; Mass Spectrometry; Peptide Library; Peptidyl Transferases; RNA, Catalytic
Life Sciences | Medicine and Health Sciences
The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.
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Citation: Bioorg Med Chem. 2004 Mar 1;12(5):927-33. Link to article on publisher's site
DOI of Published Version
Bioorganic and medicinal chemistry
Cui, Zhiyong; Sun, Lele; and Zhang, Biliang, "A peptidyl transferase ribozyme capable of combinatorial peptide synthesis" (2004). GSBS Student Publications. 257.