GSBS Student Publications

Title

A peptidyl transferase ribozyme capable of combinatorial peptide synthesis

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date

2004-02-26

UMMS Affiliation

Graduate School of Biomedical Sciences; Program in Molecular Medicine

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.

DOI of Published Version

10.1016/j.bmc.2003.12.018

Source

Bioorg Med Chem. 2004 Mar 1;12(5):927-33. Link to article on publisher's site

Journal/Book/Conference Title

Bioorganic and medicinal chemistry

Related Resources

Link to article in PubMed

PubMed ID

14980605

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