JNK1 is required for T cell-mediated immunity against Leishmania major infection
Biochemistry & Molecular Pharmacology
Graduate School of Biomedical Sciences; Program in Molecular Medicine
Life Sciences | Medicine and Health Sciences
c-Jun N-terminal kinase (JNK) is a mitogen-activated protein kinase that plays important regulatory roles in helper T cell differentiation. In the current study, we used Jnk1-deficient mice to examine the function of JNK during an in vivo pathogenic infection, leishmaniasis, which is strongly influenced by Th1/Th2 effector mechanisms. The data show that Jnk1-deficient mice, despite their usually genetically resistant background, were unable to resolve Leishmania infections. Jnk1-/- mice displayed reduced delayed-type hypersensitivity in response to the pathogen, which was associated with a T cell defect. We found that, although these mice can direct an apparent Th1-response, there is also simultaneous generation of Leishmania-specific Th2 responses, which possibly down-modulate protective Th1-mediated immune function. These findings demonstrate that the negative regulation of Th2 cytokine production by the JNK1 signaling pathway is essential for generating Th1-polarized immunity against intracellular pathogens, such as Leishmania major.
DOI of Published Version
J Immunol. 2000 Sep 1;165(5):2671-6.
Journal of immunology (Baltimore, Md. : 1950)
Constant SL, Dong C, Yang DD, Wysk MA, Davis RJ, Flavell RA. (2000). JNK1 is required for T cell-mediated immunity against Leishmania major infection. GSBS Student Publications. https://doi.org/10.4049/jimmunol.165.5.2671. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/244