GSBS Student Publications


The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat

GSBS Program

Biochemistry & Molecular Pharmacology

Publication Date


UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology; Department of Anatomy

Document Type



Life Sciences | Medicine and Health Sciences


Both epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1) have been shown to accelerate eruption of teeth in rodents. We compared the effects of neonatal injections of EGF (1 micrograms/g body weight) and CSF-1 (10(6) units) alone or together on the eruption of incisors and first molars. EGF accelerated the eruption of incisors with no significant effect on first molars. CSF-1, in contrast, accelerated molar eruption more than incisor eruption. CSF-1, but not EGF, increased the numbers of mononuclear cells in the dental follicle and osteoclasts on adjacent alveolar bone surfaces around the first molar and produced enhanced resorption of crypt surfaces as revealed by scanning electron microscopy. These data suggest that during eruption rodent incisors and molars may preferentially respond to different molecular regulators.

DOI of Published Version



Connect Tissue Res. 1995;32(1-4):165-9.

Journal/Book/Conference Title

Connective tissue research

Related Resources

Link to article in PubMed

PubMed ID