GSBS Student Publications

Title

Eaten to death

Student Author(s)

Charles Nelson

GSBS Program

Interdisciplinary Graduate Program

UMMS Affiliation

Department of Cancer Biology

Date

12-1-2014

Document Type

Article

Disciplines

Cell Biology | Cellular and Molecular Physiology

Abstract

Macro-autophagy (hereafter referred to as autophagy) delivers cytoplasmic material to the lysosome for degradation, and has been implicated in many cellular processes, including stress, infection, survival and death. Although the regulation and role of autophagy in stress, infection and survival is apparent, its involvement during cell death remains relatively unclear. In this review, we highlight what is known about the role that autophagy can play during physiological cell death, and discuss the implications of better understanding cellular destruction that involves autophagy.

DOI of Published Version

10.1111/febs.13114

Source

FEBS J. 2014 Dec;281(24):5411-7. doi: 10.1111/febs.13114. Epub 2014 Nov 10. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

ATG genes, apoptosis, autophagy, cell death, necrosis

Journal Title

The FEBS journal

PubMed ID

25323556

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