Eaten to death
Interdisciplinary Graduate Program
Department of Cancer Biology
Cell Biology | Cellular and Molecular Physiology
Macro-autophagy (hereafter referred to as autophagy) delivers cytoplasmic material to the lysosome for degradation, and has been implicated in many cellular processes, including stress, infection, survival and death. Although the regulation and role of autophagy in stress, infection and survival is apparent, its involvement during cell death remains relatively unclear. In this review, we highlight what is known about the role that autophagy can play during physiological cell death, and discuss the implications of better understanding cellular destruction that involves autophagy.
DOI of Published Version
FEBS J. 2014 Dec;281(24):5411-7. doi: 10.1111/febs.13114. Epub 2014 Nov 10. Link to article on publisher's site
ATG genes, apoptosis, autophagy, cell death, necrosis
The FEBS journal
Nelson, Charles and Baehrecke, Eric H., "Eaten to death" (2014). GSBS Student Publications. 2050.