Luciferins behave like drugs
Department of Biochemistry and Molecular Pharmacology
Biochemistry | Medicinal Chemistry and Pharmaceutics | Medicinal-Pharmaceutical Chemistry | Molecular and Cellular Neuroscience
The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation of these experiments. In this Viewpoint, we discuss bioluminescent imaging probes for the enzyme fatty acid amide hydrolase (FAAH) and the broader implications for optical imaging and drug delivery in the brain.
FAAH, bioluminescence imaging, blood-brain barrier, drug delivery, luciferase, luciferin
DOI of Published Version
ACS chemical neuroscience
Mofford DM, Miller SC. (2015). Luciferins behave like drugs. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1021/acschemneuro.5b00195. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/2049