GSBS Student Publications

Title

Luciferins behave like drugs

Student Author(s)

David M. Mofford

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

8-19-2015

Document Type

Article

Disciplines

Biochemistry | Medicinal Chemistry and Pharmaceutics | Medicinal-Pharmaceutical Chemistry | Molecular and Cellular Neuroscience

Abstract

The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation of these experiments. In this Viewpoint, we discuss bioluminescent imaging probes for the enzyme fatty acid amide hydrolase (FAAH) and the broader implications for optical imaging and drug delivery in the brain.

DOI of Published Version

10.1021/acschemneuro.5b00195

Source

ACS Chem Neurosci. 2015 Aug 19;6(8):1273-5. doi: 10.1021/acschemneuro.5b00195. Epub 2015 Jul 30. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

FAAH, bioluminescence imaging, blood-brain barrier, drug delivery, luciferase, luciferin

Journal Title

ACS chemical neuroscience

PubMed ID

26225810

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