Title
Heterologous immunity: immunopathology, autoimmunity and protection during viral infections
UMMS Affiliation
Department of Pathology
Publication Date
2011-06-01
Document Type
Article
Disciplines
Immunity | Immunology of Infectious Disease | Immunopathology
Abstract
Heterologous immunity is a common phenomenon present in all infections. Most of the time it is beneficial, mediating protective immunity, but in some individuals that have the wrong crossreactive response it leads to a cascade of events that result in severe immunopathology. Infections have been associated with autoimmune diseases such as diabetes, multiple sclerosis and lupus erythematosis, but also with unusual autoimmune like pathologies where the immune system appears dysregulated, such as, sarcoidosis, colitis, panniculitis, bronchiolitis obliterans, infectious mononucleosis and even chronic fatigue syndrome. Here we review the evidence that to better understand these autoreactive pathologies it requires an evaluation of how T cells are regulated and evolve during sequential infections with different pathogens under the influence of heterologous immunity.
Keywords
Heterologous immunity, T-cell cross-reactivity, autoimmunity, viruses, immune modeling
DOI of Published Version
10.3109/08916934.2011.523277
Source
Autoimmunity. 2011 Jun;44(4):328-47. doi: 10.3109/08916934.2011.523277. Epub 2011 Jan 20. Link to article on publisher's site
Journal/Book/Conference Title
Autoimmunity
Related Resources
PubMed ID
21250837
Repository Citation
Selin LK, Wlodarczyk MF, Kraft AR, Nie S, Kenney LL, Puzone R, Celada F. (2011). Heterologous immunity: immunopathology, autoimmunity and protection during viral infections. GSBS Student Publications. https://doi.org/10.3109/08916934.2011.523277. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/2040