GSBS Student Publications

Title

mTOR-dependent cell survival mechanisms

Student Author(s)

Chien-Min Hung

GSBS Program

Interdisciplinary Graduate Program

Publication Date

2012-12-01

UMMS Affiliation

Program in Molecular Medicine

Document Type

Article

Disciplines

Biochemistry | Cellular and Molecular Physiology

Abstract

The mechanistic target of rapamycin (mTOR) kinase is a conserved regulator of cell growth, proliferation, and survival. In cells, mTOR is the catalytic subunit of two complexes called mTORC1 and mTORC2, which have distinct upstream regulatory signals and downstream substrates. mTORC1 directly senses cellular nutrient availability while indirectly sensing circulating nutrients through growth factor signaling pathways. Cellular stresses that restrict growth also impinge on mTORC1 activity. mTORC2 is less well understood and appears only to sense growth factors. As an integrator of diverse growth regulatory signals, mTOR evolved to be a central signaling hub for controlling cellular metabolism and energy homoeostasis, and defects in mTOR signaling are important in the pathologies of cancer, diabetes, and aging. Here we discuss mechanisms by which each mTOR complex might regulate cell survival in response to metabolic and other stresses.

DOI of Published Version

10.1101/cshperspect.a008771

Source

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a008771. doi: 10.1101/cshperspect.a008771. Link to article on publisher's site

Journal/Book/Conference Title

Cold Spring Harbor perspectives in biology

Related Resources

Link to Article in PubMed

PubMed ID

23124837

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