GSBS Student Publications

Student Author(s)

Kelly N. Hallstrom

GSBS Program

Immunology & Microbiology

UMMS Affiliation

Department of Microbiology and Physiological Systems

Date

4-15-2016

Document Type

Article

Disciplines

Immunology and Infectious Disease | Microbiology

Abstract

Salmonella enterica Typhimurium employs type III secreted effectors to induce cellular invasion and pathogenesis. We previously reported the secreted effector SipA is in part responsible for inducing the apical accumulation of the host membrane protein PERP, a host factor we have shown is key to the inflammatory response induced by Salmonella. We now report that the S. Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface. To our knowledge, this is the first report demonstrating a role for SipC in directing the trafficking of a host membrane protein to the cell surface. In sum, facilitation of PERP trafficking appears to be a result of type III secreted effector-mediated recruitment of vesicles to the apical surface. Our study therefore reveals a new role for SipC, and builds upon previous reports suggesting recruitment of vesicles to the cell surface is important for Salmonella invasion.

Rights and Permissions

© 2016 Kelly N. Hallstrom and Beth A. McCormick.

DOI of Published Version

10.1080/19490976.2015.1128626

Source

Gut Microbes. 2016;7(2):136-45. doi: 10.1080/19490976.2015.1128626. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

Salmonella, host pathogen interactions, inflammation, trafficking, type III secretion

Journal Title

Gut microbes

PubMed ID

27078059

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.