GSBS Student Publications
Title
The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection
GSBS Program
Immunology & Microbiology
UMMS Affiliation
Department of Microbiology and Physiological Systems
Date
4-15-2016
Document Type
Article
Disciplines
Immunology and Infectious Disease | Microbiology
Abstract
Salmonella enterica Typhimurium employs type III secreted effectors to induce cellular invasion and pathogenesis. We previously reported the secreted effector SipA is in part responsible for inducing the apical accumulation of the host membrane protein PERP, a host factor we have shown is key to the inflammatory response induced by Salmonella. We now report that the S. Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface. To our knowledge, this is the first report demonstrating a role for SipC in directing the trafficking of a host membrane protein to the cell surface. In sum, facilitation of PERP trafficking appears to be a result of type III secreted effector-mediated recruitment of vesicles to the apical surface. Our study therefore reveals a new role for SipC, and builds upon previous reports suggesting recruitment of vesicles to the cell surface is important for Salmonella invasion.
Rights and Permissions
© 2016 Kelly N. Hallstrom and Beth A. McCormick.
DOI of Published Version
10.1080/19490976.2015.1128626
Source
Gut Microbes. 2016;7(2):136-45. doi: 10.1080/19490976.2015.1128626. Link to article on publisher's site
Related Resources
Keywords
Salmonella, host pathogen interactions, inflammation, trafficking, type III secretion
Journal Title
Gut microbes
PubMed ID
27078059
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
Repository Citation
Hallstrom, Kelly N. and McCormick, Beth A., "The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection" (2016). GSBS Student Publications. 2030.
https://escholarship.umassmed.edu/gsbs_sp/2030