Student Author(s)

Kelly N. Hallstrom

Academic Program

Immunology & Microbiology

UMMS Affiliation

Department of Microbiology and Physiological Systems

Publication Date

2016-04-15

Document Type

Article

Disciplines

Immunology and Infectious Disease | Microbiology

Abstract

Salmonella enterica Typhimurium employs type III secreted effectors to induce cellular invasion and pathogenesis. We previously reported the secreted effector SipA is in part responsible for inducing the apical accumulation of the host membrane protein PERP, a host factor we have shown is key to the inflammatory response induced by Salmonella. We now report that the S. Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface. To our knowledge, this is the first report demonstrating a role for SipC in directing the trafficking of a host membrane protein to the cell surface. In sum, facilitation of PERP trafficking appears to be a result of type III secreted effector-mediated recruitment of vesicles to the apical surface. Our study therefore reveals a new role for SipC, and builds upon previous reports suggesting recruitment of vesicles to the cell surface is important for Salmonella invasion.

Keywords

Salmonella, host pathogen interactions, inflammation, trafficking, type III secretion

Rights and Permissions

© 2016 Kelly N. Hallstrom and Beth A. McCormick.

DOI of Published Version

10.1080/19490976.2015.1128626

Source

Gut Microbes. 2016;7(2):136-45. doi: 10.1080/19490976.2015.1128626. Link to article on publisher's site

Journal/Book/Conference Title

Gut microbes

Related Resources

Link to Article in PubMed

PubMed ID

27078059

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