Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung
Graduate School of Biomedical Sciences; Department of Pathology; Department of Molecular Genetics and Microbiology
Life Sciences | Medicine and Health Sciences
A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.
DOI of Published Version
Nat Immunol. 2001 Nov;2(11):1067-76. Link to article on publisher's site
Chen HD, Fraire AE, Joris I, Brehm MA, Welsh RM, Selin LK. (2001). Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung. Morningside Graduate School of Biomedical Sciences Student Publications. https://doi.org/10.1038/ni727. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/201