Interdisciplinary Graduate Program
Program in Molecular Medicine
Biochemistry | Molecular and Cellular Neuroscience
Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper control of this local translation. Here, we find that the deadenylase CNOT7 dynamically regulates dendritic mRNA translation and transport, as well as synaptic plasticity and higher cognitive function. In cultured hippocampal neurons, synaptic stimulation induces a rapid decrease in CNOT7, which, in the short-term, results in poly(A) tail lengthening of target mRNAs. However, at later times following stimulation, decreased poly(A) and dendritic localization of mRNA take place, similar to what is observed when CNOT7 is depleted over several days. In mice, CNOT7 is essential for hippocampal-dependent learning and memory. This study identifies CNOT7 as an important regulator of RNA transport and translation in dendrites, as well as higher cognitive function.
CNOT7, polyadenylation, deadenylation, translation, RNA transport
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Copyright 2017 The Author(s)
DOI of Published Version
Cell Rep. 2017 Jul 18;20(3):683-696. doi: 10.1016/j.celrep.2017.06.078. Link to article on publisher's website
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
McFleder, Rhonda L.; Mansur, Fernanda; and Richter, Joel D., "Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function" (2017). GSBS Student Publications. 2003.