Department of Neurobiology; Lois Lab
Neuroscience and Neurobiology
Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the importance of identifying the wiring diagrams of brain circuits. To address this issue, several new approaches have been recently developed. In this review, we describe several methods that are currently available to investigate the structure and connectivity of the brain, and discuss their strengths and limitations.
brain circuit, connectomics, neuron, synapse, wiring diagram
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© 2017 The Author(s).
DOI of Published Version
Fly (Austin). 2017 Feb 16:1-15. doi: 10.1080/19336934.2017.1295189. [Epub ahead of print] Link to article on publisher's website
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Lee D, Huang T, De La Cruz A, Callejas A, Lois C. (2017). Methods to investigate the structure and connectivity of the nervous system. GSBS Student Publications. https://doi.org/10.1080/19336934.2017.1295189. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/2000