GSBS Student Publications

Title

Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics

Student Author(s)

Keith Tully

GSBS Program

Neuroscience

Publication Date

2005-01-31

UMMS Affiliation

Department of Neurobiology; Treistman Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Document Type

Article

Disciplines

Molecular and Cellular Neuroscience

Abstract

Chronic ethanol exposure increases the density of N-type calcium channels in brain. We report that ethanol increases levels of mRNA for a splice variant of the N channel specific subunit alpha1 2.2 that lacks exon 31a. Whole cell recordings demonstrated an increase in N-type current with a faster activation rate and a shift in activation to more negative potentials after chronic alcohol exposure, consistent with increased abundance of channels containing this variant. These results identify a novel mechanism whereby chronic ethanol exposure can increase neuronal excitability by altering levels of channel splice variants.

DOI of Published Version

10.1016/j.febslet.2004.12.043

Source

FEBS Lett. 2005 Jan 31;579(3):671-6. Link to article on publisher's site

Journal/Book/Conference Title

FEBS letters

Related Resources

Link to Article in PubMed

PubMed ID

15670827

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