GSBS Student Publications
Title
Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics
GSBS Program
Neuroscience
Publication Date
2005-01-31
UMMS Affiliation
Department of Neurobiology; Treistman Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Document Type
Article
Disciplines
Molecular and Cellular Neuroscience
Abstract
Chronic ethanol exposure increases the density of N-type calcium channels in brain. We report that ethanol increases levels of mRNA for a splice variant of the N channel specific subunit alpha1 2.2 that lacks exon 31a. Whole cell recordings demonstrated an increase in N-type current with a faster activation rate and a shift in activation to more negative potentials after chronic alcohol exposure, consistent with increased abundance of channels containing this variant. These results identify a novel mechanism whereby chronic ethanol exposure can increase neuronal excitability by altering levels of channel splice variants.
DOI of Published Version
10.1016/j.febslet.2004.12.043
Source
FEBS Lett. 2005 Jan 31;579(3):671-6. Link to article on publisher's site
Journal/Book/Conference Title
FEBS letters
Related Resources
PubMed ID
15670827
Repository Citation
Newton, Philip M.; Tully, Keith; McMahon, Thomas; Connolly, Jackie; Dadgar, Jahan; Treistman, Steven N.; and Messing, Robert O., "Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics" (2005). GSBS Student Publications. 1970.
https://escholarship.umassmed.edu/gsbs_sp/1970