Title
Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics
Academic Program
Neuroscience
UMMS Affiliation
Department of Neurobiology; Treistman Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Publication Date
2005-01-31
Document Type
Article
Disciplines
Molecular and Cellular Neuroscience
Abstract
Chronic ethanol exposure increases the density of N-type calcium channels in brain. We report that ethanol increases levels of mRNA for a splice variant of the N channel specific subunit alpha1 2.2 that lacks exon 31a. Whole cell recordings demonstrated an increase in N-type current with a faster activation rate and a shift in activation to more negative potentials after chronic alcohol exposure, consistent with increased abundance of channels containing this variant. These results identify a novel mechanism whereby chronic ethanol exposure can increase neuronal excitability by altering levels of channel splice variants.
DOI of Published Version
10.1016/j.febslet.2004.12.043
Source
FEBS Lett. 2005 Jan 31;579(3):671-6. Link to article on publisher's site
Journal/Book/Conference Title
FEBS letters
Related Resources
PubMed ID
15670827
Repository Citation
Newton PM, Tully K, McMahon T, Connolly J, Dadgar J, Treistman SN, Messing RO. (2005). Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics. GSBS Student Publications. https://doi.org/10.1016/j.febslet.2004.12.043. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1970