Student Author(s)

Timothy Rooney

Academic Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Freeman Lab; Graduate School of Biomedical Sciences, MD/PhD Program

Publication Date

2014-03-13

Document Type

Article

Disciplines

Developmental Neuroscience | Genetics | Molecular and Cellular Neuroscience

Abstract

Neurite degeneration is a hallmark feature of nearly all neurodegenerative diseases, occurs after most brain trauma, and is thought to be the underlying cause of functional loss in patients. Understanding the genetic basis of neurite degeneration represents a major challenge in the neuroscience field. If it is possible to define key signaling pathways that promote neurite destruction, their blockade represents an exciting new potential therapeutic approach to suppressing neurological loss in patients. This review highlights recently developed models that can be used to study fundamental aspects of neuronal injury using the fruit fly Drosophila. The speed, precision, and powerful molecular-genetic tools available in the fruit fly make for an attractive system in which to dissect neuronal signaling after injury. Their use has led to the identification of some of the first molecules whose endogenous function includes promoting axonal degeneration after axotomy, and these signaling pathways appear functionally well conserved in mammals.

Keywords

axon, dSarm, Hiw, Phr1, Sarm1, Wallerian degeneration, Wlds

Rights and Permissions

© Published by Oxford University Press 2014. This work is written by US Government employees and is in the public domain in the US.

DOI of Published Version

10.1093/ilar/ilt057

Source

ILAR J. 2014;54(3):291-5. doi: 10.1093/ilar/ilt057. Link to article on publisher's site

Journal/Book/Conference Title

ILAR journal / National Research Council, Institute of Laboratory Animal Resources

Related Resources

Link to Article in PubMed

PubMed ID

24615442

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