Department of Neurobiology; Emery Lab; Graduate School of Biomedical Sciences, Neuroscience Program
Behavioral Neurobiology | Cell Biology | Cellular and Molecular Physiology
Light is a crucial input for circadian clocks. In Drosophila, short light exposure can robustly shift the phase of circadian behavior. The model for this resetting posits that circadian photoreception is cell autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM), and promotes its degradation, which is mediated by JETLAG (JET). However, it was recently proposed that interactions between circadian neurons are also required for phase resetting. We identify two groups of neurons critical for circadian photoreception: the morning (M) and the evening (E) oscillators. These neurons work synergistically to reset rhythmic behavior. JET promotes acute TIM degradation cell autonomously in M and E oscillators but also nonautonomously in E oscillators when expressed in M oscillators. Thus, upon light exposure, the M oscillators communicate with the E oscillators. Because the M oscillators drive circadian behavior, they must also receive inputs from the E oscillators. Hence, although photic TIM degradation is largely cell autonomous, neural cooperation between M and E oscillators is critical for circadian behavioral photoresponses.
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Copyright © 2014 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
DOI of Published Version
Cell Rep. 2014 May 8;7(3):601-8. doi: 10.1016/j.celrep.2014.03.044. Epub 2014 Apr 17. Link to article on publisher's site
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Lamba P, Wentworth D, Emery P, Zhang Y. (2014). Morning and evening oscillators cooperate to reset circadian behavior in response to light input. GSBS Student Publications. https://doi.org/10.1016/j.celrep.2014.03.044. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1956