Student Author(s)

Pallavi Lamba

Academic Program

Neuroscience

UMMS Affiliation

Department of Neurobiology; Emery Lab; Graduate School of Biomedical Sciences, Neuroscience Program

Publication Date

2014-05-08

Document Type

Article

Disciplines

Behavioral Neurobiology | Cell Biology | Cellular and Molecular Physiology

Abstract

Light is a crucial input for circadian clocks. In Drosophila, short light exposure can robustly shift the phase of circadian behavior. The model for this resetting posits that circadian photoreception is cell autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM), and promotes its degradation, which is mediated by JETLAG (JET). However, it was recently proposed that interactions between circadian neurons are also required for phase resetting. We identify two groups of neurons critical for circadian photoreception: the morning (M) and the evening (E) oscillators. These neurons work synergistically to reset rhythmic behavior. JET promotes acute TIM degradation cell autonomously in M and E oscillators but also nonautonomously in E oscillators when expressed in M oscillators. Thus, upon light exposure, the M oscillators communicate with the E oscillators. Because the M oscillators drive circadian behavior, they must also receive inputs from the E oscillators. Hence, although photic TIM degradation is largely cell autonomous, neural cooperation between M and E oscillators is critical for circadian behavioral photoresponses.

Rights and Permissions

Copyright © 2014 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

DOI of Published Version

10.1016/j.celrep.2014.03.044

Source

Cell Rep. 2014 May 8;7(3):601-8. doi: 10.1016/j.celrep.2014.03.044. Epub 2014 Apr 17. Link to article on publisher's site

Journal/Book/Conference Title

Cell reports

Related Resources

Link to Article in PubMed

PubMed ID

24746814

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