GSBS Student Publications

Title

The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment

Student Author(s)

Emily M. Mallick

GSBS Program

Immunology & Microbiology

Publication Date

2014-09-01

UMMS Affiliation

Department of Microbiology and Physiological Systems; Department of Pathology

Document Type

Article

Disciplines

Cell and Developmental Biology | Cell Biology | Microbiology | Pathogenic Microbiology

Abstract

Enterohaemorrhagic Escherichia coli (EHEC) colonizes the intestine and causes bloody diarrhoea and kidney failure by producing Shiga toxin. Upon binding intestinal cells, EHEC triggers a change in host cell shape, generating actin 'pedestals' beneath bound bacteria. To investigate the importance of pedestal formation to disease, we infected genetically engineered mice incapable of supporting pedestal formation by an EHEC-like mouse pathogen, or wild type mice with a mutant of that pathogen incapable of generating pedestals. We found that pedestal formation promotes attachment of bacteria to the intestinal mucosa and vastly increases the severity of Shiga toxin-mediated disease.

DOI of Published Version

10.1111/cmi.12302

Source

Cell Microbiol. 2014 Sep;16(9):1405-24. doi: 10.1111/cmi.12302. Epub 2014 Jun 2. Link to article on publisher's site

Journal/Book/Conference Title

Cellular microbiology

Related Resources

Link to Article in PubMed

PubMed ID

24780054

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