GSBS Student Publications

Title

HCMV infection: modulating the cell cycle and cell death

Student Author(s)

Jonathan Patrick Castillo

Publication Date

2004-01-24

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Document Type

Article

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

Human cytomegalovirus (HCMV) is a member of the Herpesviridae family and is recognized as a significant pathogen to certain subgroups of the human population. It has become apparent that HCMV manipulation of the host cell cycle as well as the immune response promotes the replication and propagation of the virus. The ability of HCMV to modulate components of the host immune system and the response to infection most likely contributes to the pathology associated with this virus. This review will address the mechanisms HCMV has adapted to modulate the cell cycle to promote viral replication as well as the different ways it can prevent the "death" of an infected cell.

DOI of Published Version

10.1080/08830180490265565

Source

Int Rev Immunol. 2004 Jan-Apr;23(1-2):113-39. Link to article on publisher's website

Journal/Book/Conference Title

International reviews of immunology

Related Resources

Link to article in PubMed

PubMed ID

14690857

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