GSBS Student Publications


SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases

Student Author(s)

Gwendolyn Bennett

GSBS Program

Interdisciplinary Graduate Program

UMMS Affiliation

Program in Molecular Medicine



Document Type



Biochemistry, Biophysics, and Structural Biology | Cellular and Molecular Physiology | Genetics and Genomics


The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (gammaH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.

Rights and Permissions

Citation: DNA Repair (Amst). 2015 Jun;30:38-45. doi: 10.1016/j.dnarep.2015.03.006. Epub 2015 Mar 25. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to Article in PubMed

Journal Title

DNA repair

PubMed ID