Academic Program
Neuroscience
UMMS Affiliation
RNA Therapeutics Institute
Publication Date
2013-08-08
Document Type
Article
Disciplines
Molecular and Cellular Neuroscience | Nervous System Diseases | Neurology | Neuroscience and Neurobiology
Abstract
BACKGROUND: Neuromyelitis optica (NMO) is a devastating inflammatory disorder of the optic nerves and spinal cord characterized by frequently recurring exacerbations of humoral inflammation. NMO is associated with the highly specific NMO-IgG biomarker, an antibody that binds the aquaporin-4 water channel. Aquaporin-4 is present on glial endfeet in the central nervous system (CNS). In humans, the NMO-IgG portends more frequent exacerbations and a worse long-term clinical outcome.
METHODS: We tested the longer-term outcome of mice with EAE injected with NMO-IgG and followed them for 60 days. Clinical exams and pathology of the spinal cord and optic nerves were compared to mice that received control human IgG.
RESULTS: Passively transferred human NMO-IgG leads to more severe neurology disability over two months after onset of disease. Clinical worsening is associated with an increased concentration of large demyelinating lesions primarily to subpial AQP4-rich regions of the spinal cord.
CONCLUSIONS: NMO-IgG is pathogenic in the context of EAE in mice.
Keywords
Neuromyelitis optica, Aquaporin-4, NMO-IgG, Astrocytes, Experimental autoimmune encephalomyelitis
Rights and Permissions
© 2013 Saini et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI of Published Version
10.1186/1471-2377-13-104
Source
Saini H, Rifkin R, Gorelik M, Huang H, Ferguson Z, Jones MV, Levy M. Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis. BMC Neurol. 2013 Aug 8;13:104. doi: 10.1186/1471-2377-13-104. Link to article on publisher's site
Journal/Book/Conference Title
BMC neurology
Related Resources
PubMed ID
23927715
Repository Citation
Saini H, Rifkin R, Gorelik M, Huang H, Ferguson Z, Jones MV, Levy M. (2013). Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis. GSBS Student Publications. https://doi.org/10.1186/1471-2377-13-104. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1833
Included in
Molecular and Cellular Neuroscience Commons, Nervous System Diseases Commons, Neurology Commons