GSBS Student Publications

Student Author(s)

Harleen Saini

GSBS Program

Neuroscience

Publication Date

2013-08-08

UMMS Affiliation

RNA Therapeutics Institute

Document Type

Article

Disciplines

Molecular and Cellular Neuroscience | Nervous System Diseases | Neurology | Neuroscience and Neurobiology

Abstract

BACKGROUND: Neuromyelitis optica (NMO) is a devastating inflammatory disorder of the optic nerves and spinal cord characterized by frequently recurring exacerbations of humoral inflammation. NMO is associated with the highly specific NMO-IgG biomarker, an antibody that binds the aquaporin-4 water channel. Aquaporin-4 is present on glial endfeet in the central nervous system (CNS). In humans, the NMO-IgG portends more frequent exacerbations and a worse long-term clinical outcome.

METHODS: We tested the longer-term outcome of mice with EAE injected with NMO-IgG and followed them for 60 days. Clinical exams and pathology of the spinal cord and optic nerves were compared to mice that received control human IgG.

RESULTS: Passively transferred human NMO-IgG leads to more severe neurology disability over two months after onset of disease. Clinical worsening is associated with an increased concentration of large demyelinating lesions primarily to subpial AQP4-rich regions of the spinal cord.

CONCLUSIONS: NMO-IgG is pathogenic in the context of EAE in mice.

Keywords

Neuromyelitis optica, Aquaporin-4, NMO-IgG, Astrocytes, Experimental autoimmune encephalomyelitis

Rights and Permissions

© 2013 Saini et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version

10.1186/1471-2377-13-104

Source

Saini H, Rifkin R, Gorelik M, Huang H, Ferguson Z, Jones MV, Levy M. Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis. BMC Neurol. 2013 Aug 8;13:104. doi: 10.1186/1471-2377-13-104. Link to article on publisher's site

Journal/Book/Conference Title

BMC neurology

Related Resources

Link to article in PubMed

PubMed ID

23927715

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