GSBS Student Publications

Title

Structure and function of nematode RNA-binding proteins

Student Author(s)

LiangMeng Wee

GSBS Program

Interdisciplinary Graduate Program

Publication Date

2010-06-01

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Document Type

Article

Disciplines

Structural Biology

Abstract

RNA-binding proteins are critical effectors of gene expression. They guide mRNA localization, translation, and stability, and potentially play a role in regulating mRNA synthesis. The structural basis for RNA recognition by RNA-binding proteins is the key to understand how they target specific transcripts for regulation. Compared to other metazoans, nematode genomes contain a significant expansion in several RNA-binding protein families, including Pumilio-FBF (PUF), TTP-like zinc finger (TZF), and Argonaute-like (AGO) proteins. Genetic data suggest that individual members of each family have distinct functions, presumably due to sequence variations that alter RNA-binding specificity or protein interaction partners. In this review, we highlight example structures and identify the variable regions that likely contribute to functional divergence in nematodes.

DOI of Published Version

10.1016/j.sbi.2010.03.010

Source

Curr Opin Struct Biol. 2010 Jun;20(3):305-12. doi: 10.1016/j.sbi.2010.03.010. Link to article on publisher's website

Journal/Book/Conference Title

Current opinion in structural biology

Related Resources

Link to article in PubMed

PubMed ID

20418095

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