Title
Translational control of mitochondrial energy production mediates neuron morphogenesis
Academic Program
Interdisciplinary Graduate Program
UMMS Affiliation
Program in Molecular Medicine
Publication Date
2012-12-05
Document Type
Article
Disciplines
Cell and Developmental Biology
Abstract
Mitochondrial energy production is a tightly regulated process involving the coordinated transcription of several genes, catalysis of a plethora of posttranslational modifications, and the formation of very large molecular supercomplexes. The regulation of mitochondrial activity is particularly important for the brain, which is a high-energy-consuming organ that depends on oxidative phosphorylation to generate ATP. Here we show that brain mitochondrial ATP production is controlled by the cytoplasmic polyadenylation-induced translation of an mRNA encoding NDUFV2, a key mitochondrial protein. Knockout mice lacking the Cytoplasmic Polyadenylation Element Binding protein 1 (CPEB1) have brain-specific dysfunctional mitochondria and reduced ATP levels, which is due to defective polyadenylation-induced translation of electron transport chain complex I protein NDUFV2 mRNA. This reduced ATP results in defective dendrite morphogenesis of hippocampal neurons both in vitro and in vivo. These and other results demonstrate that CPEB1 control of mitochondrial activity is essential for normal brain development.
DOI of Published Version
10.1016/j.cmet.2012.11.002
Source
Cell Metab. 2012 Dec 5;16(6):789-800. doi: 10.1016/j.cmet.2012.11.002. Link to article on publisher's site
Journal/Book/Conference Title
Cell Metabolism
Related Resources
PubMed ID
23217258
Repository Citation
Oruganty-Das A, Ng T, Udagawa T, Goh EL, Richter JD. (2012). Translational control of mitochondrial energy production mediates neuron morphogenesis. GSBS Student Publications. https://doi.org/10.1016/j.cmet.2012.11.002. Retrieved from https://escholarship.umassmed.edu/gsbs_sp/1827