GSBS Student Publications

Title

Translational control of mitochondrial energy production mediates neuron morphogenesis

Student Author(s)

Aparna Oruganty-Das

GSBS Program

Interdisciplinary Graduate Program

Publication Date

2012-12-05

UMMS Affiliation

Program in Molecular Medicine

Document Type

Article

Disciplines

Cell and Developmental Biology

Abstract

Mitochondrial energy production is a tightly regulated process involving the coordinated transcription of several genes, catalysis of a plethora of posttranslational modifications, and the formation of very large molecular supercomplexes. The regulation of mitochondrial activity is particularly important for the brain, which is a high-energy-consuming organ that depends on oxidative phosphorylation to generate ATP. Here we show that brain mitochondrial ATP production is controlled by the cytoplasmic polyadenylation-induced translation of an mRNA encoding NDUFV2, a key mitochondrial protein. Knockout mice lacking the Cytoplasmic Polyadenylation Element Binding protein 1 (CPEB1) have brain-specific dysfunctional mitochondria and reduced ATP levels, which is due to defective polyadenylation-induced translation of electron transport chain complex I protein NDUFV2 mRNA. This reduced ATP results in defective dendrite morphogenesis of hippocampal neurons both in vitro and in vivo. These and other results demonstrate that CPEB1 control of mitochondrial activity is essential for normal brain development.

DOI of Published Version

10.1016/j.cmet.2012.11.002

Source

Cell Metab. 2012 Dec 5;16(6):789-800. doi: 10.1016/j.cmet.2012.11.002. Link to article on publisher's site

Journal/Book/Conference Title

Cell Metabolism

Related Resources

Link to article in PubMed

PubMed ID

23217258

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